Chemical Structure : NE26394
CAS No.:
NE26394
Catalog No.: PC-27389Not For Human Use, Lab Use Only.
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins.
NE26394 has much weaker downregulation of the close homologue CDK6 with DC50 of >10 uM, shows no activity for kinases CDK1, CDK2, CDK5, CDK7, CDK9, GSK3α and GSK3β.
NE26394 is a selective CRBN-based molecular glue recruiting CDK4-INK4 complexes.
NE26394 inhibits RB-E2F pathway activity in CDK4-dependent cancer cells, broadly suppresses E2F target protein expression across CDK4-dependent and RB-proficient prostate cancer cell lines.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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