Chemical Structure : XZ8078
CAS No.:
XZ8078
(XZ-8078)
Catalog No.: PC-27235Not For Human Use, Lab Use Only.
XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM.
XZ8078 displays potent cell growth inhibitory activities against HR-proficient and clinically used PARPi-resistant cancer cells, with efficacy significantly superior to that of AZD5305.
XZ8078 demonstrates excellent tumor growth inhibition (TGI) in the AZD5305-sensitive/-insensitive xenograft model with TGI values of 133.6% and 71.9%, respectively.
Physicochemical Properties
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M.Wt
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840.92
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Formula
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C45H45FN10O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2,6-dioxopiperidin-3-yl)-5-((R)-3-((4-((R)-7-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-5-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)piperidin-1-yl)methyl)pyrrolidin-1-yl)isoindoline-1,3-dione
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References
1. Xuetao Zhang, et al. J Med Chem. 2026 Jun 30. doi: 10.1021/acs.jmedchem.6c00239.
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