Chemical Structure : NUCC-0227579
CAS No.:
NUCC-0227579
(NUCC0227579, CD73 degrader C79)
Catalog No.: PC-27236Not For Human Use, Lab Use Only.
NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways.
C79 eliminated CD73 at the cell surface and intracellular compartments across multiple human cancer cell lines, abolishing nucleotidase activity and more effectively reversing adenosine-mediated immunosuppression than enzymatic inhibitors.
C79 enhanced NF-κB/NFAT signaling, increased IFN-γ and TNF-α production, and promoted human CD8+ T cell activation and proliferation.
C79 impaired tumor cell metabolic fitness, proliferation, migration, and adhesion through non-nucleotidase-dependent mechanisms.
C79 significantly suppressed tumor growth while enhancing antitumor immune responses humanized NSG mouse models of TNBC.
Physicochemical Properties
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M.Wt
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450.89
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Formula
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C24H15ClN8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((5-(4-chloro-1-(1H-indazol-6-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrazol-1-yl)methyl)benzonitrile
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References
1. Ping Xie, et al. J Med Chem. 2026 Jul 9;69(13):15630-15652.
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