SMARCA2 4 MGD Compound 1 | SMARCA2/4 degrader

Chemical Structure : SMARCA2 4 MGD Compound 1

SMARCA2 4 MGD Compound 1 (SMARCA2/4 MGD Compound 1)

Catalog No.: PC-27544Not For Human Use, Lab Use Only.

SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173.

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Biological Activity

SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173.

Physicochemical Properties

M.Wt	495.63
Formula	C29H33N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-amino-5-(8-(2-(3-(piperidin-1-yl)prop-1-yn-1-yl)pyridin-4-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazin-3-yl)phenol

References

1. Rouhimoghadam M, et al. Cell Chem Biol. 2026 Jul 2:S2451-9456(26)00198-4.

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SMARCA2 4 MGD Compound 1 (SMARCA2/4 MGD Compound 1)

Biological Activity

Physicochemical Properties

References

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