APH02174 | IRAK4 PROTAC | Probechem Biochemicals

Chemical Structure : APH02174

Catalog No.: PC-27227Not For Human Use, Lab Use Only.

APH02174 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 4.01 nM, Dmax=94%.

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Biological Activity

APH02174 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 4.01 nM, Dmax=94%.

M.Wt	870.02
Formula	C49H55N7O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1'-(((1r,4r)-4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)cyclohexyl)methyl)-6-(4-(hydroxymethyl)piperidin-1-yl)-3H-spiro[benzofuran-2,4'-piperidin]-5-yl)furo[3,2-b]pyridine-3-carboxamide

1. Wu XW, et al. J Med Chem. 2025 Jun 26;68(12):12845-12861.