Chemical Structure : NSD2 degrader T9
CAS No.:
3108071-48-0
NSD2 degrader T9
Catalog No.: PC-27167Not For Human Use, Lab Use Only.
NSD2 degrader T9 is a potent, selective, FBXO22-recruiting NSD2 degrader with DC50 of 0.37 uM in in HEK293T-NSD2-HiBiT cells (4 h).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NSD2 degrader T9 is a potent, selective, FBXO22-recruiting NSD2 degrader with DC50 of 0.37 uM in in HEK293T-NSD2-HiBiT cells (4 h).
T9 (0.1–10 uM) induces significant, dose-dependent degradation of both the long and short isoforms of NSD2.
T9 acts rapidly to induce FBXO22-mediated NSD2 elimination, acts through the ubiquitin–proteasome system (UPS).
PWWP1 engagement is required for PROTAC-mediated recruitment and subsequent proteasomal degradation.
T9 exhibits an exquisite selectivity profile, NSD2 degradation proceeds through compound-induced NSD2-FBXO22 ternary complex formation, ubiquitin transfer, and proteasome engagement, rather than by indirect or off-target effect.
Covalent engagement of FBXO22 by T9 occurs specifically through C326.
T9 (10 uM) robustly suppressed PC3 cell growth to roughly 45%, but not UNC8732.
Physicochemical Properties
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M.Wt
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642.71
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Formula
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C38H34N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-cyclopropyl-N-(4-((2-(2-(4-formylphenyl)acetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
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References
1. Tang H, et al. J Med Chem. 2026 Jun 29. doi: 10.1021/acs.jmedchem.6c00020.
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