SMD-1087 | SMARCA2 PROTAC | Probechem Biochemicals

Chemical Structure : SMD-1087

Catalog No.: PC-27121Not For Human Use, Lab Use Only.

SMD-1087 is a highly potent, selective SMARCA2 PROTAC degrader with DC50 of 9 nM, with limited activity against SMARCA4.

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Biological Activity

SMD-1087 is a highly potent, selective SMARCA2 PROTAC degrader with DC50 of 9 nM, with limited activity against SMARCA4.

M.Wt	986.71
Formula	C56H68ClN7O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-((1r,4S)-4-((4-(4'-chloro-5'-oxo-5'H-spiro[cyclohexane-1,7'-indolo[1,2-a]quinazolin]-10'-yl)piperidin-1-yl)methyl)cyclohexane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

1. Leng L, et al. J Med Chem. 2025 Jan 23;68(2):1113-1133.