Chemical Structure : JHK-02-108-2
CAS No.:
JHK-02-108-2
Catalog No.: PC-27200Not For Human Use, Lab Use Only.
JHK-02-108-2 is a potent, selective, type II, heterobifunctional CDK6 PROTAC degrader with DC50 of 11 nM in MOLT-4 cells, does not induce CDK5 degradation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JHK-02-108-2 is a potent, selective, type II, heterobifunctional CDK6 PROTAC degrader with DC50 of 11 nM in MOLT-4 cells, does not induce CDK5 degradation.
JHK-02-108-2 induces CDK6 degradation via the ubiquitin-proteasome system (UPS).
JHK-02-108-2 induces ternary complex formation between CDK6 and CRBN with EC50 of 0.22 uM in TR-FRET assays.
JHK-02-108-2 exhibits a growth inhibition with IC50 value of 0.64 μM and dose-dependent G1 arrest in MOLT-4 cells.
JHK-02-108-2 induces potent cell cycle arrest in GBM and AML cells.
Physicochemical Properties
|
M.Wt
|
989.04
|
|
Formula
|
C49H56F4N10O8
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-(4-(3-(4-((4-(8-(2-((1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)acetamido)octyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
|
References
1. Ji Hyeon Kim, et al. J Am Chem Soc. 2026 Jun 26. doi: 10.1021/jacs.6c10277.
Contact Us
sales@probechem.com
