DW-229 | KDM PROTAC | Probechem Biochemicals

Chemical Structure : DW-229

DW-229 (DW229)

Catalog No.: PC-27220Not For Human Use, Lab Use Only.

DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity.

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Biological Activity

Physicochemical Properties

M.Wt	679.77
Formula	C38H41N5O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hex-1-yn-1-yl)-N-(6-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)hexyl)benzamide

References

1. Johnston A, et al. ACS Omega. 2026;11(18):26421-26437.

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DW-229 (DW229)

Biological Activity

Physicochemical Properties

References

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