Chemical Structure : SMD-6346
CAS No.:
3086248-19-0
SMD-6346
(SMD6346)
Catalog No.: PC-27120Not For Human Use, Lab Use Only.
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%).
SMD-6346 potently and effectively inhibits cell growth in SMARCA4-deficient cancer cell lines and displays minimal cell growth inhibition activity in SMARCA2/4 wild-type cancer cell lines.
SMD-6346 induces robust SMARCA2 depletion in tumor tissues in mice and significantly inhibits tumor growth in the H838 SMARCA4-deficient xenograft model in mice.
Physicochemical Properties
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M.Wt
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810.38
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Formula
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C46H50ClF2N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(4-(3-((4-(4'-chloro-5'-oxo-5'H-spiro[cyclohexane-1,7'-indolo[1,2-a]quinazolin]-10'-yl)piperidin-1-yl)methyl)-1-oxa-9-azaspiro[5.5]undecan-9-yl)-2,6-difluorophenyl)piperidine-2,6-dione
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References
1. Leng L, et al. J Med Chem. 2026 Jun 23. doi: 10.1021/acs.jmedchem.6c01093.
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