RAD51 PROTAC G73

Chemical Structure : RAD51 PROTAC G73

Catalog No.: PC-27164Not For Human Use, Lab Use Only.

RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells.

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Biological Activity

RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells.
G73 promotes RAD51 degradation by recruiting E3 ligase VHL to RAD51, enabling subsequent ubiquitination, induces degradation in a time- and VHL-dependent manner.
G73 enhances DNA damage and exhibits synergistic effects with the PARP inhibitor olaparib.
G73 potentiates PARP inhibitors to suppress tumor growth in xenograft mouse models.

Physicochemical Properties

M.Wt	1158.74
Formula	C57H69ClFN9O12S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2S,4R)-2-(((S)-1-(2-chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-(((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-2,12-dioxo-6,9-dioxa-3,13-diazahexadecyl)oxy)pyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide

References

1. Yanlin Jian, et al. Acta Pharm Sin B. 2026 Jun;16(6):3907-3919.

RAD51 PROTAC G73

Biological Activity

Physicochemical Properties

References

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