APH003 | IRAK4 PROTAC | Probechem Biochemicals

Chemical Structure : APH003

Catalog No.: PC-27226Not For Human Use, Lab Use Only.

APH003 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 1.28 nM, DC90=6.39 nM.

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Biological Activity

APH003 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 1.28 nM, DC90=6.39 nM.

M.Wt	863.95
Formula	C44H50FN11O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1'-(2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-5-fluoro-1-methyl-1H-indazol-6-yl)-4-hydroxypiperidin-4-yl)acetyl)-6-(4-(hydroxymethyl)piperidin-1-yl)-3H-spiro[benzofuran-2,4'-piperidin]-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

1. Xi-Wei Wu, et al. J Med Chem. 2026 Jun 26. doi: 10.1021/acs.jmedchem.6c00828.