HDAC6 PROTAC 15

Chemical Structure : HDAC6 PROTAC 15

Catalog No.: PC-27096Not For Human Use, Lab Use Only.

HDAC6 PROTAC 15 is a potent, selective HDAC6 degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation.

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Biological Activity

HDAC6 PROTAC 15 is a potent, selective HDAC6 PROTAC degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation.

Physicochemical Properties

M.Wt	662.70
Formula	C37H34N4O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)ethynyl)phenyl)-N-hydroxy-4-(tetrahydro-2H-pyran-4-carbonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-8-carboxamide

References

1. Ripa L, et al. ACS Med Chem Lett. 2026 Jun 1;17(6):1294-1302.

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HDAC6 PROTAC 15

Biological Activity

Physicochemical Properties

References

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