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Chemical Structure : DAS-CHO-5-oCRBN
CAS No.:
Catalog No.: PC-21653Not For Human Use, Lab Use Only.
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells.
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|---|---|---|---|
| 2 mg | $398 | In stock | |
| 5 mg | $598 | In stock | |
| 10 mg | $858 | In stock | |
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DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells.
DAS-CHO-5-oCRBN does not significantly inhibit the c-Src signaling in cells.
DAS-CHO-5-oCRBN exhibits antiproliferative activity in c-Src-dependent cell lines (MDA-MB-231, GI50=62 nM) with similar pharmacology to siRNA knockdown of c-Src.
| M.Wt | 883.99 | |
| Formula | C45H45N11O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((6-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)-2-oxoethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-4-phenoxyphenyl)thiazole-5-carboxamide |
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1. Mao W, et al. ACS Chem Biol. 2023 Dec 19. doi: 10.1021/acschembio.3c00548.
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