Chemical Structure : SelDeg51
CAS No.:
3036372-80-9
SelDeg51
(Selective Degrader of FKBP51)
Catalog No. : PC-21336Not For Human Use, Lab Use Only.
SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC degrader with Kd of 18 nM, Emax=90%.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2133601
Biological Activity
SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC degrader with Kd of 18 nM, Emax=90%.
Physicochemical Properties
M.Wt
1343.62
Formula
C72H91FN8O14S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(1R)-3-(3,4-dimethoxyphenyl)-1-(4-((1-(3-(2-(((2S,4R)-1-(2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)propyl (2S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate
References
1. Thomas M Geiger, et al. Angew Chem Int Ed Engl.
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