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Chemical Structure : DBr-1
Catalog No.: PC-21642Not For Human Use, Lab Use Only.
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.
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DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.
DBr-1 shows a similar degradation preference as the CRBN-based PROTAC dBRD9, only strongly affecting BRD9 but unlike the VZ185 not BRD7 levels.
DBr-1 potently degrades BRD9 with a DC50 of 90 nM but only weakly affected BRD7 protein levels in HEK293/BRD9-HiBiT and HEK293/BRD7-HiBiT cells, respectively.
| M.Wt | 970.66 | |
| Formula | C55H68ClN9O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schröder M, et al. Nat Commun. 2024 Jan 4;15(1):275.
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