Catalog No.: PC-21642Not For Human Use, Lab Use Only.
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.
DBr-1 shows a similar degradation preference as the CRBN-based PROTAC dBRD9, only strongly affecting BRD9 but unlike the VZ185 not BRD7 levels.
DBr-1 potently degrades BRD9 with a DC50 of 90 nM but only weakly affected BRD7 protein levels in HEK293/BRD9-HiBiT and HEK293/BRD7-HiBiT cells, respectively.
