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Chemical Structure : WD6305
Catalog No.: PC-21676Not For Human Use, Lab Use Only.
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line.
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WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line.
WD6305 caused a 71.4% degradation of METTL3 protein at 1 μM after 24h in Mono-Mac-6 cells, a METTL3-expressed AML cell line.
WD6305 induced rapid degradation of METTL3 protein within 2 h and nearly completely abolished METTL3 protein after a 12-h treatment at 500 nM.
WD6305 effectively reduced METTL14 protein level in a dose-dependent manner with a DC50 of 194 nM, with no significant effect on WTAP protein levels.
WD6305 induces degradation of the METTL3-METTL14 complex through the ubiquitin-proteasomal system.
WD6305 inhibits m6A modification and proliferation, and induces apoptosis in AML cell lines, has more potent anti-leukemic activity compared to its parent METTL3 inhibitor (UZH2, Cat#PC-49679).
| M.Wt | 1112.40 | |
| Formula | C61H75F2N11O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenhao Du, et al. Cell Chem Biol. 2024 Jan 2:S2451-9456(23)00439-7.
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