CXJ2080 | CDK7 PROTAC | Probechem Biochemicals

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Chemical Structure : CXJ2080

CXJ2080 (CXJ-2080)

Catalog No.: PC-26461Not For Human Use, Lab Use Only.

CXJ2080 is a potent, selective CDK7 PROTAC degrader with DC50 of 0.88 nM and Dmax >98% in MV4-11 cells, disrupts the CDK7-cyclin H-MAT1 complex, simultaneously suppressing MYC-driven oncogenic signaling while activating the p53-p21 tumor suppressor axis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	1030.75
Formula	C51H68ClN11O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R)-1-(2-(4-(7-(((1r,4r)-4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)cyclohexyl)amino)-7-oxoheptyl)-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

References

1. Tu Y, et al. Leukemia. 2026 Mar 25. doi: 10.1038/s41375-026-02925-2.

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CXJ2080 (CXJ-2080)

Biological Activity

Physicochemical Properties

References

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