| Cat. No. |
Product Name |
Information |
| PC-25017 |
DK-I-56-1
α6 GABAA receptor PAM
|
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations. |
| PC-24988 |
GABAA receptor agonist CTMB
GABAA receptor agonist
|
CTMB is an allosteric agonist of GABAA receptors, positively modulates GABAA receptors and inhibits voltage-regulated sodium channels (NaVs) to suppress neuronal membrane depolarization. |
| PC-24815 |
Droperidol
CAS 548-73-2
|
Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist, inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR) with IC50 of 12.6 nM and 5.8 μM, also specifically inhibits YTHDF2 and prevents associations of YTHDF2 with DDX1 and eIF3F. |
| PC-24505 |
Flumazenil
GABAA antagonist
|
Flumazenil is a central benzodiazepine receptor (IC50=9.91 nM) and competitive GABAA receptor antagonist, reverses the sedative effects of benzodiazepines on the central nervous system. |
| PC-24259 |
L-838417
⍺2,3,5 GABAA receptor PAM
|
L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively. |
| PC-24258 |
ENX-101
⍺2,3,5 GABAA receptor PAM
|
ENX-101 is a α2,α3,α5-selective γ-aminobutyric acid type A (GABAA) receptor partial positive allosteric modulator (PAM), deuterated analog of L-838,417. |
| PC-24174 |
Refisolone
GABAA antagonist
|
Refisolone is a potent GABAA receptor antagonist with potential for treatment of migraine. |
| PC-24158 |
Moxetomidate hydrochloride
GABAA agonist
|
Moxetomidate hydrochloride (ET-26 HCl, Methoxyethyl etomidate hydrochloride) is a novel etomidate analogue and short-acting anesthetic drug, a GABAA receptor agonist. |
| PC-24157 |
Moxetomidate
GABAA agonist
|
Moxetomidate (ET-26) is a novel etomidate analogue and short-acting anesthetic drug, a GABAA receptor agonist. |
| PC-24010 |
CGP55845 hydrochloride
GABAB antagonist
|
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with IC50 of 6 nM, high selective over GABAA receptors. |
| PC-23662 |
Picrotoxin
GABAA receptor antagonist
|
Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor (GABA AR), binds to the interface pocket on the GABAR, causes overstimulation and induces convulsions. |
| PC-22890 |
MP-III-022
α5GABAARs PAM
|
MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively. |
