| Cat. No. |
Product Name |
Information |
| PC-24259 |
L-838417
⍺2,3,5 GABAA receptor PAM
|
L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively. |
| PC-24258 |
ENX-101
⍺2,3,5 GABAA receptor PAM
|
ENX-101 is a α2,α3,α5-selective γ-aminobutyric acid type A (GABAA) receptor partial positive allosteric modulator (PAM), deuterated analog of L-838,417. |
| PC-24174 |
Refisolone
GABAA antagonist
|
Refisolone is a potent GABAA receptor antagonist with potential for treatment of migraine. |
| PC-24158 |
Moxetomidate hydrochloride
GABAA agonist
|
Moxetomidate hydrochloride (ET-26 HCl, Methoxyethyl etomidate hydrochloride) is a novel etomidate analogue and short-acting anesthetic drug, a GABAA receptor agonist. |
| PC-24157 |
Moxetomidate
GABAA agonist
|
Moxetomidate (ET-26) is a novel etomidate analogue and short-acting anesthetic drug, a GABAA receptor agonist. |
| PC-24010 |
CGP55845 hydrochloride
GABAB antagonist
|
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with IC50 of 6 nM, high selective over GABAA receptors. |
| PC-23986 |
Muscimol
GABA agonist, NINJ1 inhibitor
|
Muscimol (Agarin) is a psychoactive isoxazole and selective neurotransmitter GABA agonist, binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with EC50 of 200 nM, also is a small molecule inhibitor of ninjurin-1 (NINJ1) oligomerization and NINJ1 mediated membrane rupture. |
| PC-23662 |
Picrotoxin
GABAA receptor antagonist
|
Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor (GABA AR), binds to the interface pocket on the GABAR, causes overstimulation and induces convulsions. |
| PC-22890 |
MP-III-022
α5GABAARs PAM
|
MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively. |
| PC-22282 |
Lesogaberan hydrochloride
GABAB agonist
|
Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
| PC-22281 |
NS16085
GABAA α2/α3 agonist
|
NS16085 is a potent, selective alpha2/alpha3 subtype-selective GABA(A) receptor positive allosteric modulator, dsplays negligible efficacy at GABAA-α5 receptors. |
| PC-22151 |
SL651498
GABAARa agonist
|
SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM). |
