| Cat. No. |
Product Name |
Information |
| PC-45628 |
Lorediplon
GABAA PAM
|
Lorediplon is a partial positive allosteric GABAA receptor modulator, displays activity at the alpha1-subunit, associated with promoting sleep. |
| PC-45060 |
Basmisanil
GABAA α5 NAM
|
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors. |
| PC-46124 |
Baclofen
GABAB agonist, VDCC inhibitor
|
Baclofen is a derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-45171 |
(R)-Baclofen
GABAB agonist, VDCC inhibitor
|
(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-28513 |
Cinazepam
GABAA receptor agonist
|
Cinazepam (Nalobrazepam, BD-798) is a partial GABAA receptor agonist with anxiolytic and sedative properties. |
| PC-28342 |
Bicuculline
GABAA antagonist
|
Bicuculline ((+)-Bicuculline) is a competing neurotransmitter GABAA receptor antagonist with IC50 of 2 uM, shows neuroprotective and anticonvulsant activity. |
| PC-28340 |
GlyphAllo
GABAA PAM
|
GlyphAllo (SPT-300, Glyph Allopregnanolone) is an oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport, shows neuroactive steroid antidepressant and anxiolytic activity via GABAA (γ-aminobutyric acid type A) receptor positive allosteric modulation. |
| PC-28339 |
Allopregnanolone
GABAA PAM
|
Allopregnanolone (ALLO) is an endogenous neuroactive steroid, has antidepressant and anxiolytic activity, is a positive allosteric modulator of the GABAA receptor. |
| PC-28240 |
Cenobamate
GABAA PAM
|
Cenobamate (YKP3089) is an antiepileptic compound that acts as a positive allosteric modulator of high-affinity GABAA receptors, potentiates GABA-induced currents (IGABA) in acutely isolated CA3 pyramidal cells with EC50 of 164 uM. |
| PC-26748 |
α5IA
α5 GABAA receptor inverse agonist
|
α5IA (alpha5IA, L-822179) is a selective inverse agonist selective for α5 subunit-containing GABAA receptors, enhances cognition. |
| PC-26582 |
YX84
GABA A receptor PAM
|
YX84 is a slow-onset, potent positive allosteric modulator (PAM) of GABA A receptor with EC50 of 0.9 uM. |
| PC-25539 |
Isoguvacine hydrochloride
GABAAR agonist
|
Isoguvacine hydrochloride is a potent and selective agonist of the GABA(A) receptor (GABA(A)R). |
