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Picrotoxin

Chemical Structure : Picrotoxin

CAS No.: 124-87-8

Picrotoxin (Cocculin)

Catalog No.: PC-23662Not For Human Use, Lab Use Only.

Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor (GABA AR), binds to the interface pocket on the GABAR, causes overstimulation and induces convulsions.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor (GABA AR), binds to the interface pocket on the GABAR, causes overstimulation and induces convulsions.

Physicochemical Properties

M.Wt
Formula C15H18O7.C15H16O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-, compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)

References

1. Boulanger JJ, et al. Neuroscience. 2017 Aug 18. pii: S0306-4522(17)30584-5.

2. Carpenter TS, et al. Chem Res Toxicol. 2013 Oct 21;26(10):1444-54.

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