MP-III-022

Chemical Structure : MP-III-022

Catalog No.: PC-22890Not For Human Use, Lab Use Only.

MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively.

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Biological Activity

Physicochemical Properties

M.Wt	372.40
Formula	C22H17FN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-8-ethynyl-6-(2-fluorophenyl)-N,4-dimethyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxamide

References

1. Stamenić TT, et al. Eur J Pharmacol. 2016 Nov 15;791:433-443.

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MP-III-022

Biological Activity

Physicochemical Properties

References

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