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Chemical Structure : Lesogaberan hydrochloride
Catalog No.: PC-22282Not For Human Use, Lab Use Only.
Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).
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Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).
Lesogaberan (AZD3355) potently stimulates recombinant human GABAB receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) through a peripheral mode of action in vivo, shows potential for treatment of GERD.
| M.Wt | 177.54 | |
| Formula | C3H10ClFNO2P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boeckxstaens GE, et al. Gut. 2011 Sep;60(9):1182-8.
2. Alstermark C, et al. J Med Chem. 2008 Jul 24;51(14):4315-20.
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