| Cat. No. |
Product Name |
Information |
| PC-42225 |
U-93631
GABAA antagonist
|
U-93631 (U93631) is a potent GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. |
| PC-45628 |
Lorediplon
GABAA PAM
|
Lorediplon is a partial positive allosteric GABAA receptor modulator, displays activity at the alpha1-subunit, associated with promoting sleep. |
| PC-45060 |
Basmisanil
GABAA α5 NAM
|
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors. |
| PC-46124 |
Baclofen
GABAB agonist, VDCC inhibitor
|
Baclofen is a derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-45171 |
(R)-Baclofen
GABAB agonist, VDCC inhibitor
|
(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-25539 |
Isoguvacine hydrochloride
GABAAR agonist
|
Isoguvacine hydrochloride is a potent and selective agonist of the GABA(A) receptor (GABA(A)R). |
| PC-25269 |
QH-ii-66
α5-GABAA receptor agonist
|
QH-ii-66 is a potent, selective agonist of α5-GABAA receptor (GABRA5). |
| PC-25268 |
SR-419
α5-GABAA receptor inhibitor
|
SR-419 is a BBB-impermeable, selective α5-GABAA receptor (GABRA5) inhibitor, shows specific binding to the benzodiazepine site of the GABRA5 receptor, exhibits potent peripheral analgesic effects. |
| PC-25067 |
EL-0052
GABAAR modulator
|
EL-0052 (Lorotomidate, 4-Fluoroetomidate) is a small molecule γ-aminobutyric acid A receptor (GABAAR) modulator, enhances GABAA receptors currents with EC50 of 0.98 uM. |
| PC-25018 |
PZ-II-029
α6 GABAA receptor PAM
|
PZ-II-029 is a selective, positive allosteric modulator (PAM) of α6 subunit-containing GABAA receptor, potentiates α6β3γ2S GABAA receptor‐mediated GABA currents. |
| PC-25017 |
DK-I-56-1
α6 GABAA receptor PAM
|
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations. |
| PC-24988 |
GABAA receptor agonist CTMB
GABAA receptor agonist
|
CTMB is an allosteric agonist of GABAA receptors, positively modulates GABAA receptors and inhibits voltage-regulated sodium channels (NaVs) to suppress neuronal membrane depolarization. |
