| Cat. No. |
Product Name |
Information |
| PC-45628 |
Lorediplon
GABAA PAM
|
Lorediplon is a partial positive allosteric GABAA receptor modulator, displays activity at the alpha1-subunit, associated with promoting sleep. |
| PC-45060 |
Basmisanil
GABAA α5 NAM
|
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors. |
| PC-46124 |
Baclofen
GABAB agonist, VDCC inhibitor
|
Baclofen is a derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-45171 |
(R)-Baclofen
GABAB agonist, VDCC inhibitor
|
(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-25067 |
EL-0052
GABAAR modulator
|
EL-0052 (Lorotomidate, 4-Fluoroetomidate) is a small molecule γ-aminobutyric acid A receptor (GABAAR) modulator, enhances GABAA receptors currents with EC50 of 0.98 uM. |
| PC-25018 |
PZ-II-029
α6 GABAA receptor PAM
|
PZ-II-029 is a selective, positive allosteric modulator (PAM) of α6 subunit-containing GABAA receptor, potentiates α6β3γ2S GABAA receptor‐mediated GABA currents. |
| PC-25017 |
DK-I-56-1
α6 GABAA receptor PAM
|
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations. |
| PC-24988 |
GABAA receptor agonist CTMB
GABAA receptor agonist
|
CTMB is an allosteric agonist of GABAA receptors, positively modulates GABAA receptors and inhibits voltage-regulated sodium channels (NaVs) to suppress neuronal membrane depolarization. |
| PC-24815 |
Droperidol
CAS 548-73-2
|
Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist, inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR) with IC50 of 12.6 nM and 5.8 μM, also specifically inhibits YTHDF2 and prevents associations of YTHDF2 with DDX1 and eIF3F. |
| PC-24505 |
Flumazenil
GABAA antagonist
|
Flumazenil is a central benzodiazepine receptor (IC50=9.91 nM) and competitive GABAA receptor antagonist, reverses the sedative effects of benzodiazepines on the central nervous system. |
| PC-24259 |
L-838417
⍺2,3,5 GABAA receptor PAM
|
L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively. |
| PC-24258 |
ENX-101
⍺2,3,5 GABAA receptor PAM
|
ENX-101 is a α2,α3,α5-selective γ-aminobutyric acid type A (GABAA) receptor partial positive allosteric modulator (PAM), deuterated analog of L-838,417. |
