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(R)-Baclofen

Chemical Structure : (R)-Baclofen

CAS No.: 69308-37-8

(R)-Baclofen (STX-209, Arbaclofen)

Catalog No.: PC-45171Not For Human Use, Lab Use Only.

(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist.
(R)-Baclofen also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM.
(R)-Baclofen is a neurotransmitter inhibitor by blocking the release of excitatory transmitters.
(R)-Baclofen serves as a central nervous system depressant and skeletal muscle relaxant.

Physicochemical Properties

M.Wt 213.6608
Formula C10H12ClNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 5 mg/mL (Need ultrasonic)

Chemical Name/SMILES

Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-

References

1. Zvejniece L, et al. Pharmacol Biochem Behav. 2015 Oct;137:23-9.

2. Carter LP, et al. Pharmacol Ther. 2009 Jan;121(1):100-14.

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