Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Basmisanil
CAS No.: 1159600-41-5
Catalog No.: PC-45060Not For Human Use, Lab Use Only.
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors.
Basmisanil (RG1662) displays >90-fold selectivity versus α1, α2, and α3 subunit-containing receptors.
Basmisanil (RG1662) inhibits GABA-induced currents at GABAA-α5, yet has little or no effect at the other receptor subtypes.
Basmisanil (RG1662) attenuated diazepam-induced spatial learning impairment in rats (Morris water maze), improved executive function in non-human primates (object retrieval), without showing anxiogenic or proconvulsant effects in rats.
| M.Wt | 445.464 | |
| Formula | C21H20FN3O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
Methanone, (1,1-dioxido-4-thiomorpholinyl)[6-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]- |
|
1. Myers JF, et al. J Cereb Blood Flow Metab. 2017 Jun;37(6):2137-2148.
2. Costa AC, et al. CNS Drugs. 2013 Sep;27(9):679-702.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
