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Droperidol

Chemical Structure : Droperidol

CAS No.: 548-73-2

Droperidol (Dehydrobenzperidol)

Catalog No.: PC-24815Not For Human Use, Lab Use Only.

Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist, inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR) with IC50 of 12.6 nM and 5.8 μM, also specifically inhibits YTHDF2 and prevents associations of YTHDF2 with DDX1 and eIF3F.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist, inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR) with IC50 of 12.6 nM and 5.8 μM, also specifically inhibits YTHDF2 and prevents associations of YTHDF2 with DDX1 and eIF3F.

Physicochemical Properties

M.Wt 379.44
Formula C22H22FN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

References

1. Liu T, et al. Mol Cell. 2025 May 28:S1097-2765(25)00454-X.

2. Pamela Flood, et al. Anesthesiology. 2002 Apr;96(4):987-93.

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