Chemical Structure : DK-I-56-1
CAS No.:
2055050-92-3
DK-I-56-1
Catalog No.: PC-25017Not For Human Use, Lab Use Only.
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations.
DK-I-56-1 is the deuterated version of PZ-II-029.
DK-I-56-1 does not or only weakly modulates GABA-induced currents at αxβ3γ2 GABAA receptors containing α1, α2, α3, α4, or α5 subunits below 1 µM concentration.
DK-I-56-1 inhibited the development and reduced the established trigeminal neuropathic pain in a rat model of chronic constriction injury of the infraorbital branch of the trigeminal nerve.
Physicochemical Properties
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M.Wt
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324.35
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Formula
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C18H12D3N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-methoxy-2-(4-(methoxy-d3)phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
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References
1. Vasović D, et al. Eur J Pain. 2019 May;23(5):973-984.
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