| Cat. No. |
Product Name |
Information |
| PC-47098 |
ASP8062
GABAB PAM
|
ASP8062 is a potent, selective GABA B receptor positive allosteric modulator (PAM), positive allosteric modulating activity for human and rat GABAB receptors, exerts analgesic effects in rat model of fibromyalgia. |
| PC-38727 |
SGS742
GABAB antagonist
|
CGP 36742 (SGS-742) is a BBB-penetrant GABAB receptor antagonist, discretely up-regulates GABAB receptor binding sites. |
| PC-38491 |
Imidazenil
GABAA modulator
|
Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM. |
| PC-38382 |
Alogabat
GABAA α5 PAM
|
Alogabat (RG7816, RO7017773) is a potent, selective GABAA-α5 receptors positive allosteric modulator (PAM) with Ki of 7.9 nM for GABAA-α5β3γ2 receptors in rats, 37-, 26-, and 18-fold selectivity over GABAA α1β3γ2, α2β3γ2, and α3β3γ2, respectively. |
| PC-73410 |
Cipepofol
GABA potentiator
|
Cipepofol (HSK3486) is a small molecule γ-aminobutyric acid (GABA) receptor potentiator and new sedative-hypnotic agent and a promising intravenous anaesthetic candidate. |
| PC-73213 |
CGP52432
GABAB antagonist
|
CGP52432 is a potent, selective GABAB receptor antagonist with IC50 of 85 nM. |
| PC-38319 |
Zuranolone
GABAA receptor modulator
|
Zuranolone (SAGE-217) is an orally active, positive allosteric modulator of the GABAA receptor with EC50 of 375/299 nM (α1β2γ2/α4β3δ). |
| PC-35484 |
HZ-166
α2/α3-GABAA PAM
|
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand / agonist with preferential activity at α2- and α3-GABA(A) receptors. |
| PC-35483 |
KRM-II-81
GABAA α2/α3 PAM
|
KRM-II-81 is a selective α2/α3 subtype GABAA receptor ligand (positive allosteric modulator) with EC50 of 937 nM for α3β3γ2 GABAAR. |
| PC-35454 |
GR3027
GABAA antagonist
|
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
| PC-63442 |
ONO-8590580
GABAA α5 PAM
|
ONO-8590580 is a novel potent, selective GABAA α5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with Ki of 7.9 nM. |
| PC-63310 |
MIDD0301
α5β3γ2 GABAA inhibitor
|
MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM, shows no significant binding at the peripheral GABAAR at 10 uM. |
