| Cat. No. |
Product Name |
Information |
| PC-22875 |
DDL-920
GABAA receptor NAM
|
DDL-920 is a potent, selective and brain permeable negative allosteric modulator (NAM) of the γ-aminobutyric acid type A receptors (GABARs), inhibits parvalbumin (PV) expressing interneurons (PV+INs) and consequently enhances γ-oscillations both in vitro and in vivo. |
| PC-21943 |
MRK-898
GABAA modulator
|
MRK-898 is an orally active GABA(A) receptor modulator, binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. |
| PC-49338 |
EVT-201
GABAA PAM
|
EVT-201 (Dimdazenil, EVT 201) is a partial positive allosteric GABA(A) receptor modulator with potential for the treatment of insomnia. |
| PC-47098 |
ASP8062
GABAB PAM
|
ASP8062 is a potent, selective GABA B receptor positive allosteric modulator (PAM), positive allosteric modulating activity for human and rat GABAB receptors, exerts analgesic effects in rat model of fibromyalgia. |
| PC-38727 |
SGS742
GABAB antagonist
|
CGP 36742 (SGS-742) is a BBB-penetrant GABAB receptor antagonist, discretely up-regulates GABAB receptor binding sites. |
| PC-38491 |
Imidazenil
GABAA modulator
|
Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM. |
| PC-38382 |
Alogabat
GABAA α5 PAM
|
Alogabat (RG7816, RO7017773) is a potent, selective GABAA-α5 receptors positive allosteric modulator (PAM) with Ki of 7.9 nM for GABAA-α5β3γ2 receptors in rats, 37-, 26-, and 18-fold selectivity over GABAA α1β3γ2, α2β3γ2, and α3β3γ2, respectively. |
| PC-73410 |
Cipepofol
GABA potentiator
|
Cipepofol (HSK3486) is a small molecule γ-aminobutyric acid (GABA) receptor potentiator and new sedative-hypnotic agent and a promising intravenous anaesthetic candidate. |
| PC-73213 |
CGP52432
GABAB antagonist
|
CGP52432 is a potent, selective GABAB receptor antagonist with IC50 of 85 nM. |
| PC-38319 |
Zuranolone
GABAA receptor modulator
|
Zuranolone (SAGE-217) is an orally active, positive allosteric modulator of the GABAA receptor with EC50 of 375/299 nM (α1β2γ2/α4β3δ). |
| PC-35484 |
HZ-166
α2/α3-GABAA PAM
|
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand / agonist with preferential activity at α2- and α3-GABA(A) receptors. |
| PC-35483 |
KRM-II-81
GABAA α2/α3 PAM
|
KRM-II-81 is a selective α2/α3 subtype GABAA receptor ligand (positive allosteric modulator) with EC50 of 937 nM for α3β3γ2 GABAAR. |
