| Cat. No. |
Product Name |
Information |
| PC-62769 |
TPA023
GABAA α2/α3 agonist
|
TPA023 is a potent, α2/α3 subtype-selective, and oral GABAA receptor agonist with Kd of 0.92, 1.05 and 0.58 nM for α1-, α2-, α3-, and α5-containing human receptors. |
| PC-62768 |
TPA023B
GABAA α2/α3 agonist
|
TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype. |
| PC-62765 |
AZD6280
GABAA α2/α3 modulator
|
AZD6280 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 7.7. |
| PC-62764 |
Lesogaberan
GABAB agonist
|
Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
| PC-62098 |
LAU159
α6β3γ2 GABAA modulator
|
LAU159 is a potent, functionally selective positive modulator of α6β3γ2 GABAA receptor with EC50 of 2.2 uM. |
| PC-62090 |
AZD7325
GABAA α2/α3 PAM
|
AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51. |
| PC-62089 |
PF-06372865
GABAA α2/α3 PAM
|
PF-06372865 (Darigabat) is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator. |
| PC-60203 |
Propyl pyrazole triol
GABAA modulator, ERα agonist
|
Propyl pyrazole triol (PPT) is an allosteric GABAA receptor modulator and a selective estrogen receptor alpha (ERα) agonist. |
| PC-42797 |
NS11394
GABAA PAM
|
NS11394 is a potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2. |
| PC-42414 |
Pagoclone
GABAA agonist
|
Pagoclone ((+)-RP-59037, IP-456) is a potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit. |
| PC-42117 |
MRK-016
GABAA α5 inverse agonist
|
MRK-016 (MRK016) is a potent, functionally selective, CNS-penetrating and orally bioavailable inverse agonist of benzodiazepine site of GABAA α5 receptor with Ki of 0.8-1.5 nM for α1-, α2-, α3-, and α5-containing GABAA receptors. |
| PC-42106 |
PK14105
|
PK14105 is a potent photoaffinity ligand for the peripheral-type benzodiazepine binding site with Ki of 4 nM. |
