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Chemical Structure : Lesogaberan
Catalog No.: PC-62764Not For Human Use, Lab Use Only.
Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).
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Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM); potently stimulates recombinant human GABAB receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) through a peripheral mode of action in vivo, shows potential for treatment of GERD.
Other Indication
Phase 2 Discontinued
| M.Wt | 141.082 | |
| Formula | C3H9FNO2P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lehmann A, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12.
2. Brändén L, et al. Eur J Pharmacol. 2010 May 25;634(1-3):138-41.
3. Alstermark C, et al. J Med Chem. 2008 Jul 24;51(14):4315-20.
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