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Chemical Structure : ONO-8590580
CAS No.: 1802661-73-9
Catalog No.: PC-63442Not For Human Use, Lab Use Only.
ONO-8590580 is a novel potent, selective GABAA α5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with Ki of 7.9 nM.
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|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
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| 1 g | Get quote |
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ONO-8590580 (ONO 8590580) is a novel potent, selective GABAA α5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with Ki of 7.9 nM.
ONO-8590580 shows functionally selective GABAA α5 NAM activity for GABA-induced Cl- channel activity with a maximum 44.4% inhibition and an EC50 of 1.1 nM.
ONO-8590580 significantly augments tetanus-induced long-term potentiation of CA1 synapse response in rat hippocampal slices at 300 nM.
ONO-8590580 significantly prevents MK-801-induced memory deficit in vivo (3-20 mg/kg, p.o.).
| M.Wt | 376.439 | |
| Formula | C21H21FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine |
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1. Kawaharada S, et al. J Pharmacol Exp Ther. 2018 Apr 19. pii: jpet.117.247627.
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