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Chemical Structure : AZD3043
Catalog No.: PC-63159Not For Human Use, Lab Use Only.
AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.
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AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.
AZD3043 potentiates and directly activates the α1β2γ2, α2β2γ2 and α2β3γ2 GABA(A) receptor subtypes, produces hypnosis and electroencephalograph depression in rats.
| M.Wt | 351.443 | |
| Formula | C19H29NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Egan TD, et al. Anesthesiology. 2012 Jun;116(6):1267-77.
2. Jonsson Fagerlund M, et al. Eur J Pharmacol. 2012 Nov 5;694(1-3):13-9.
3. Björnsson MA, et al. Anesth Analg. 2015 Oct;121(4):904-13.
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