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Chemical Structure : SL651498
Catalog No.: PC-22151Not For Human Use, Lab Use Only.
SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM).
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SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM).
SL651498 is a full agonist at recombinant rat GABA(A) receptors containing alpha2 and alpha3 subunits and as a partial agonist at recombinant GABA(A) receptors expressing alpha1 and alpha5 subunits.
SL651498 elicited anxiolytic-like activity similar to that of diazepam [minimal effective dose (MED): 1-10 mg/kg, i.p.] in three conflict models, in the elevated plus-maze, the light/dark test, and the defense test battery in rats and mice.
| M.Wt | 389.43 | |
| Formula | C23H20FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Griebel G, et al. J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.
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