L-838417 | ⍺2,3,5 GABAA receptor PAM

Chemical Structure : L-838417

CAS No.: 286456-42-6

L-838417 (L-838,417)

Catalog No.: PC-24259Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$278	In stock
25 mg	$488	In stock
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Biological Activity

L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively.
L-838417 produces anxiolytic effects in adult rat, as indexed by a transformation of social avoidance into preference and an increase in social investigation.
L-838417 eliminates social avoidance, but has no anxiolytic effects on social investigation.

Physicochemical Properties

M.Wt	399.41
Formula	C19H19F2N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine

References

1. McKernan RM, et al. Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761.

2. Mikkelsen JD, et al. Eur J Pharmacol. 2005 Sep 20;519(3):223-30.

L-838417 (L-838,417)

Biological Activity

Physicochemical Properties

References

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