MRK-067 (TPA123, TP13) | GABAA agonist

Chemical Structure : MRK-067

MRK-067 (TPA123, TP-13, MRK067)

Catalog No.: PC-28086Not For Human Use, Lab Use Only.

MRK-067 (TPA123, TP13) is a high affinity, partial agonist of α1-, α2-, α3-, and α5-containing GABAA receptors with quivalently high affinity (Ki=0.19-0.41 nM).

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Biological Activity

MRK-067 (TPA123, TP13) is a high affinity, partial agonist of α1-, α2-, α3-, and α5-containing GABAA receptors with quivalently high affinity (Ki=0.19-0.41 nM).

Physicochemical Properties

M.Wt	361.41
Formula	C19H19N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine

References

1. Nancy A Ator, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):4-16.

2. Ciara McCabe, et al. Neuropharmacology. 2004 Feb;46(2):171-8.

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MRK-067 (TPA123, TP-13, MRK067)

Biological Activity

Physicochemical Properties

References

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