Alogabat (RG7816, RO7017773)

Chemical Structure : Alogabat

CAS No.: 2230009-48-8

Catalog No.: PC-38382Not For Human Use, Lab Use Only.

Alogabat (RG7816, RO7017773) is a potent, selective GABAA-α5 receptors positive allosteric modulator (PAM) with Ki of 7.9 nM for GABAA-α5β3γ2 receptors in rats, 37-, 26-, and 18-fold selectivity over GABAA α1β3γ2, α2β3γ2, and α3β3γ2, respectively.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
50 mg		Get quote
100 mg		Get quote

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Biological Activity

Alogabat (RG7816, RO7017773) is a potent, selective GABAA-α5 receptors positive allosteric modulator (PAM) with Ki of 7.9 nM for GABAA-α5β3γ2 receptors in rats, 37-, 26-, and 18-fold selectivity over GABAA α1β3γ2, α2β3γ2, and α3β3γ2, respectively.

Alogabat (RG7816, RO 7017773) has a similar pharmacological profile in human recombinant GABAA receptor subtypes.

Alogabat enhances GABA-evoked responses of rat and human α5-containing receptors by 167% and 72%, respectively.

Alogabat potentiates other receptor subtypes to a much lesser extent than α5-containing receptors.

Alogabat normalized elevated self-grooming behavior in both Cntnap2−/− and BTBR mice and exhibited antiepileptic activity in rats.

Alogabat showed beneficial effects in mouse models relevant to neurodevelopmental disorders and anti-seizure activity.

Physicochemical Properties

M.Wt	409.446
Formula	C21H23N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)-N-(tetrahydro-2H-pyran-4-yl)pyridazine-3-carboxamide

References

1. Patent WO2018104419A1.
2. Cecere G, et al. Front Pharmacol. 2025 Jul 21;16:1626078.