Chemical Structure : Loberamisal
CAS No.:
2486316-20-3
Loberamisal
(ZL006-05)
Catalog No.: PC-28216Not For Human Use, Lab Use Only.
Loberamisal (ZL006-05) is a small-molecule compound that dually targets the postsynaptic density 95 (PSD-95) pathway and α2 γ-aminobutyric acid type α (α2-GABAA) receptor, disrupts PSD-95-nNOS interaction and selectively potentiates α2-containing GABAAR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Loberamisal (ZL006-05) is a small-molecule compound that dually targets the postsynaptic density 95 (PSD-95) pathway and α2 γ-aminobutyric acid type α (α2-GABAA) receptor, disrupts PSD-95-nNOS interaction and selectively potentiates α2-containing GABAAR.
ZL006-05 is highly effective against chronic pain without analgesic tolerance and side effects.
ZL006-05 not only abolish the SNL-induced increase in PSD-95-nNOS complex in the SDH but also show a very high affinity to α2-containing GABAAR.
ZL006-05 can avoid analgesic tolerance and unwanted side effects.
Physicochemical Properties
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M.Wt
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464.38
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Formula
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C24H27Cl2NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoate
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References
1. Li J, et al. Theranostics. 2021 Apr 3;11(12):5970-5985.
2. Wei W, et al. Neurotherapeutics. 2021 Oct;18(4):2436-2448.
3. Feng B, et al. Stroke Vasc Neurol. 2026 Aug 27;11(4):465-472.
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