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Cat. No. Product Name CAS No. Information
PC-35137

CY-09

1073612-91-5 CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity.
PC-43228

MCC950

210826-40-7 MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
PC-42228

NOD-IN-1

132819-92-2 NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively.
PC-38558

GSK669

852664-86-9 GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.
PC-38557

GSK717

1595278-21-9 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.
PC-38421

Selnoflast

2260969-36-4 Selnoflast is a potent, selective NLRP3 inhibitor.
PC-73216

NLRP3-IN-3

2254433-37-7 NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability.

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