| Cat. No. |
Product Name |
Information |
| PC-43229 |
MCC950 sodium
NLRP3 inhibitor
|
MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively. |
| PC-43228 |
MCC950
NLRP3 inhibitor
|
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3. |
| PC-61787 |
JC-171
NLRP3 inhibitor
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
| PC-42228 |
NOD-IN-1
|
NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively. |
| PC-45499 |
Nodinitib-1
NOD1 inhibitor
|
Nodinitib-1 (ML130, Noditinib-1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM. |
| PC-22372 |
NT-0249
NLRP3 inhibitor
|
NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM. |
| PC-22057 |
BAL-0028
NLRP3 inhibitor
|
BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM. |
| PC-22042 |
NLRP3 inhibitor NIC-11
NLRP3 inhibitor
|
NIC-11 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 69 nM. |
| PC-22041 |
NLRP3 inhibitor NIC-12
NLRP3 inhibitor
|
NIC-12 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 11 nM. |
| PC-21813 |
NDT-19795
NLRP3 inhibitor
|
NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM. |
| PC-21694 |
YQ128
NLRP3 inhibitor
|
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM. |
| PC-21639 |
NP3-146
NLRP3 inhibitor
|
NP3-146 is a small molecule NLRP3 inflammasome inhibitor and an analog of MCC950. |
