| Cat. No. |
Product Name |
Information |
| PC-49808 |
FK 565
NOD1 agonist
|
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49396 |
GDC-2394
NLRP3 inhibitor
|
GDC-2394 (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-49268 |
NDT-30805
NLRP3 inhibitor
|
NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs. |
| PC-38558 |
GSK669
NOD2 inhibitor
|
GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38557 |
GSK717
NOD2 inhibitor
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38421 |
Selnoflast
NLRP3 inhibitor
|
Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor. |
| PC-73216 |
NLRP3-IN-3
NLRP3 inhibitor
|
NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability. |
| PC-73215 |
Emlenoflast
NLRP3 inhibitor
|
Emlenoflast (MCC7840, Inzomelid, IZD174) is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of <100 nM. |
| PC-35385 |
INF39
NLRP3 inhibitor
|
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages. |
| PC-35137 |
CY-09
NLRP3 inhibitor
|
CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity. |
| PC-35078 |
Oridonin
NLRP3 inhibitor
|
Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
