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Cat. No. Product Name Information
PC-22042

NLRP3 inhibitor NIC-11

NLRP3 inhibitor

NIC-11 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 69 nM.
PC-22041

NLRP3 inhibitor NIC-12

NLRP3 inhibitor

NIC-12 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 11 nM.
PC-21813

NDT-19795

NLRP3 inhibitor

NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM.
PC-21694

YQ128

NLRP3 inhibitor

YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.
PC-21639

NP3-146

NLRP3 inhibitor

NP3-146 is a small molecule NLRP3 inflammasome inhibitor and an analog of MCC950.
PC-21638

NP3-562

NLRP3 inhibitor

NP3-562 is a potent, orally bioavailable NLRP3 inflammasome inhibitor, inhibits IL-1β in nigericin-stimulated THP-1 cells with IC50 of 90 nM.
PC-21637

ZYIL1

NLRP3 inhibitor

ZYIL1 is an oral small molecule NLRP3 inflammasome inhibitor, exhibits potent (IC50 in nanomolar range) in human whole blood and supresses inflammation caused by the NLRP3 inflammasome.
PC-21283

NT-0796

NLRP3 inhibitor

NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM.
PC-21282

DFV890

NLRP3 inhibitor

DFV890 (IFM-2427) is apotent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation,prevents NLRP3 inflammasome assembly in response to sterile danger signals.
PC-21079

JT002

NLRP3 inhibitor

JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis.
PC-20912

JT001

NLRP3 inhibitor

JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.
PC-20303

JC124

NLRP3 inhibitor

JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells.

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