Cat. No. |
Product Name |
Information |
PC-22042 |
NLRP3 inhibitor NIC-11
NLRP3 inhibitor
|
NIC-11 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 69 nM. |
PC-22041 |
NLRP3 inhibitor NIC-12
NLRP3 inhibitor
|
NIC-12 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 11 nM. |
PC-21813 |
NDT-19795
NLRP3 inhibitor
|
NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM. |
PC-21694 |
YQ128
NLRP3 inhibitor
|
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM. |
PC-21639 |
NP3-146
NLRP3 inhibitor
|
NP3-146 is a small molecule NLRP3 inflammasome inhibitor and an analog of MCC950. |
PC-21638 |
NP3-562
NLRP3 inhibitor
|
NP3-562 is a potent, orally bioavailable NLRP3 inflammasome inhibitor, inhibits IL-1β in nigericin-stimulated THP-1 cells with IC50 of 90 nM. |
PC-21637 |
ZYIL1
NLRP3 inhibitor
|
ZYIL1 is an oral small molecule NLRP3 inflammasome inhibitor, exhibits potent (IC50 in nanomolar range) in human whole blood and supresses inflammation caused by the NLRP3 inflammasome. |
PC-21283 |
NT-0796
NLRP3 inhibitor
|
NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
PC-21282 |
DFV890
NLRP3 inhibitor
|
DFV890 (IFM-2427) is apotent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation,prevents NLRP3 inflammasome assembly in response to sterile danger signals. |
PC-21079 |
JT002
NLRP3 inhibitor
|
JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis. |
PC-20912 |
JT001
NLRP3 inhibitor
|
JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly. |
PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |