Selnoflast (RO7486967, RG-6418, IZD334)

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Chemical Structure : Selnoflast

CAS No.: 2260969-36-4

Catalog No.: PC-38421Not For Human Use, Lab Use Only.

Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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100 mg		Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor.

Selnoflast (RO7486967, RG-6418, IZD334) inhibits IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages.

Selnoflast (RO7486967, RG-6418, IZD334) shows potential for treatment of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.

Physicochemical Properties

M.Wt	391.530
Formula	C20H29N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide

References

1. Patent WO2019008025 A1.

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