Cat. No. |
Product Name |
Information |
PC-21283 |
NT-0796
NLRP3 inhibitor
|
NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
PC-20956 |
ADS032
Inflammasome inhibitor
|
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM. |
PC-49808 |
FK 565
NOD1 agonist
|
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
PC-49396 |
GDC-2394
NLRP3 inhibitor
|
GDC-2394 (GDC-2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
PC-38558 |
GSK669
NOD2 inhibitor
|
GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
PC-38557 |
GSK717
NOD2 inhibitor
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
PC-38421 |
Selnoflast
NLRP3 inhibitor
|
Selnoflast (RO7486967) is an orally active, potent, selective and reversible small molecule NLRP3 inhibitor. |
PC-73215 |
Emlenoflast
NLRP3 inhibitor
|
Emlenoflast (MCC7840, Inzomelid, IZD174) is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of <100 nM. |
PC-35385 |
INF39
NLRP3 inhibitor
|
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages. |
PC-35137 |
CY-09
|
CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity. |
PC-35078 |
Oridonin
NLRP3 inhibitor
|
Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
PC-63450 |
NBC19
NLRP3 inhibitor
|
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |