Chemical Structure : NT-0249
CAS No.:
2763617-39-4
NT-0249
(NT0249)
Catalog No. : PC-22372Not For Human Use, Lab Use Only.
NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
Packing Price Stock Quantity 5 mg $218 In stock 0 1 2 3 4 5 10 mg $358 In stock 0 1 2 3 4 5 25 mg $558 In stock 0 1 2 3 4 5 50 mg Get quote 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2237201
Biological Activity
NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
Physicochemical Properties
M.Wt
481.55
Formula
C22H28N5NaO4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
sodium (S)-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)((N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)carbamoyl)amide
References
1. Thornton P, et al. J Pharmacol Exp Ther.
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