NT-0249 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : NT-0249

NT-0249 (NT0249)

Catalog No.: PC-22372Not For Human Use, Lab Use Only.

NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.

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Biological Activity

NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
NT-0249 potently blocked (LPS + ATP)-induced IL-1β release with IC50 of 12 nM.
NT-0249 curtails systemic inflammation and astrogliosis in preestablished obese states in mice.

Physicochemical Properties

M.Wt	481.55
Formula	C22H28N5NaO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (S)-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)((N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)carbamoyl)amide

References

1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.

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NT-0249 (NT0249)

Biological Activity

Physicochemical Properties

References

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