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Chemical Structure : NT-0249
Catalog No.: PC-22372Not For Human Use, Lab Use Only.
NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
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NT-0249 is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
NT-0249 potently blocked (LPS + ATP)-induced IL-1β release with IC50 of 12 nM.
NT-0249 curtails systemic inflammation and astrogliosis in preestablished obese states in mice.
| M.Wt | 481.55 | |
| Formula | C22H28N5NaO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.
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