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BAL-0028

Chemical Structure : BAL-0028

CAS No.: 2842012-69-3

BAL-0028 (BAL0028)

Catalog No.: PC-22057Not For Human Use, Lab Use Only.

BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM.
BAL-0028 is distinct from MCC950 and includes specific site interactions.

Physicochemical Properties

M.Wt 403.46
Formula C24H22FN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((1H-indazol-7-yl)methyl)-2-ethoxy-3'-fluoro-N-methyl-[1,1'-biphenyl]-4-carboxamide

References

1. George Hartman, et al. Bioorg Med Chem Lett. 2024 Apr 1:102:129675.

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