BAL-0028 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : BAL-0028

BAL-0028 (BAL0028)

Catalog No.: PC-22057Not For Human Use, Lab Use Only.

BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM.

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Biological Activity

BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM.
BAL-0028 is distinct from MCC950 and includes specific site interactions.

Physicochemical Properties

M.Wt	403.46
Formula	C24H22FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1H-indazol-7-yl)methyl)-2-ethoxy-3'-fluoro-N-methyl-[1,1'-biphenyl]-4-carboxamide

References

1. George Hartman, et al. Bioorg Med Chem Lett. 2024 Apr 1:102:129675.

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BAL-0028 (BAL0028)

Biological Activity

Physicochemical Properties

References

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