Chemical Structure : QX-31
CAS No.:
3065380-90-4
QX-31
(QX31)
Catalog No.: PC-28129Not For Human Use, Lab Use Only.
QX-31 is a covalent probe inhibitor of NLRP3 inflammasome, selectively engaging the autoinhibitory leucine-rich repeat (LRR) domain, covalently binds to Cysteine 838, stabilizing NLRP3 in an inactive conformation and preventing inflammasome assembly with high selectivity over AIM2 and NLRC4.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
QX-31 is a covalent probe inhibitor of NLRP3 inflammasome, selectively engaging the autoinhibitory leucine-rich repeat (LRR) domain, covalently binds to Cysteine 838, stabilizing NLRP3 in an inactive conformation and preventing inflammasome assembly with high selectivity over AIM2 and NLRC4.
QX-31 reverses maladaptive immunometabolic reprogramming within the renal microenvironment by blunting the PI3K/AKT/HIF-1α axis, suppressing aberrant glycolysis and glutaminolysis.
QX-31 demonstrates potent antifibrotic efficacy in human kidney organoids and murine models of renal injury (UUO and IRI).
Physicochemical Properties
|
M.Wt
|
417.50
|
|
Formula
|
C24H20FN3OS
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(4-((2-((4-fluorobenzyl)thio)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)acrylamide
|
References
1. Wu WH, et al. J Med Chem. 2026 Sep 10;69(17):20734-20760.
Contact Us
sales@probechem.com
