Parunoflast (VTX3232) | NLRP3 inhibitor

Chemical Structure : Parunoflast

Parunoflast (VTX3232, VTX-3232)

Catalog No.: PC-26349Not For Human Use, Lab Use Only.

Parunoflast (VTX3232) is a potent, selective, orally bioavailable and brain-penetrant NLRP3 inhibitor.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Parunoflast (VTX3232) is a potent, selective, orally bioavailable and brain-penetrant NLRP3 inhibitor.

Parunoflast (VTX3232) potently suppressed the release of proinflammatory cytokines (IL-1β, IL-18, IL-1α, IL-6, and TNF) from macrophages and microglia stimulated with metabolic stressors including palmitic acid and cholesterol crystals.

Parunoflast (VTX3232) also blocks NLRP3-driven insulin resistance in primary human hepatocytes and adipocytes while normalizing the acute phase response and FGF-21 secretion in hepatocytes under palmitic acid-induced inflammation.

Parunoflast (VTX3232) improves hyperglycemia and hepatic steatosis, and reduces markers of cardiovascular and renal disease in DIO mice.

Physicochemical Properties

M.Wt	381.40
Formula	C19H22F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-((R)-hydroxy((R)-1-methylpiperidin-3-yl)methyl)-4-methylpyridazin-3-yl)-5-(trifluoromethyl)phenol

References

1. Jennyfer Bultinck, et al. Mol Metab. 2026 Jan:103:102282.

Parunoflast (VTX3232, VTX-3232)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.