| Cat. No. |
Product Name |
Information |
| PC-35078 |
Oridonin
NLRP3 inhibitor
|
Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
| PC-63450 |
NBC19
NLRP3 inhibitor
|
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |
| PC-43229 |
MCC950 sodium
NLRP3 inhibitor
|
MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively. |
| PC-43228 |
MCC950
NLRP3 inhibitor
|
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3. |
| PC-61787 |
JC-171
NLRP3 inhibitor
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
| PC-42228 |
NOD-IN-1
NOD1/NOD2 inhibitor
|
NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively. |
| PC-45499 |
Nodinitib-1
NOD1 inhibitor
|
Nodinitib-1 (ML130, Noditinib 1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM. |
| PC-23831 |
AZD4144
NLPR3 inhibitor
|
AZD4144 is a potent, direct and selective NLPR3 inflammasome inhibitor. |
| PC-23679 |
ASP0965
NLRP3 inhibitor
|
ASP0965 is potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with IC50 of 8.4 nM (in vitro IL-1β inhibitory activity). |
| PC-23602 |
NOD1 antagonist 66
NOD1 inhibitor
|
NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively. |
| PC-23598 |
NLRP3 inhibitor compound A
NLRP3 inhibitor
|
NLRP3 inhibitor compound A is a potent, highly selective NLRP3 inflammasome inhibitor with IC50 of 67 nM for inhibition of IL-1β in PBMCs, targets ATPase activity of NLRP3 through binding to Walker A motif. |
| PC-23493 |
NP3-253
NLRP3 inhibitor
|
NP3-253 is a potent, selective and brain penetrant inhibitor of the NLRP3 inflammasome, inhibits IL-1β release in nigericin-stimulated THP-1 cells with IC50 of 0.5 nM. |
