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Cat. No. Product Name Information
PC-63450

NBC19

NLRP3 inhibitor

NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM..
PC-43229

MCC950 sodium

NLRP3 inhibitor

MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
PC-43228

MCC950

NLRP3 inhibitor

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
PC-61787

JC-171

NLRP3 inhibitor

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.
PC-42228

NOD-IN-1

NOD1/NOD2 inhibitor

NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively.
PC-45499

Nodinitib-1

NOD1 inhibitor

Nodinitib-1 (ML130, Noditinib 1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM.
PC-23602

NOD1 antagonist 66

NOD1 inhibitor

NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively.
PC-23598

NLRP3 inhibitor compound A

NLRP3 inhibitor

NLRP3 inhibitor compound A is a potent, highly selective NLRP3 inflammasome inhibitor with IC50 of 67 nM for inhibition of IL-1β in PBMCs, targets ATPase activity of NLRP3 through binding to Walker A motif.
PC-23493

NP3-253

NLRP3 inhibitor

NP3-253 is a potent, selective and brain penetrant inhibitor of the NLRP3 inflammasome, inhibits IL-1β release in nigericin-stimulated THP-1 cells with IC50 of 0.5 nM.
PC-23200

YM-I-26

NLRP3 inhibitor

YM-I-26 is a highly selective NLRP3 inflammasome inhibitor, binds to recombinant NLRP3 with Kd of 560.2 nM.
PC-22764

INF200

NLRP3 inhibitor

INF200 is a novel sulfonylurea-based NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis with IC50 of 1.55 uM, efficiently reduces cardiac and metabolic complications in in vivo model of diet-induced metaflammation.
PC-22763

INF195

NLRP3 inhibitor

INF195 is a small molecule NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis and IL-1 β release in human macrophages.

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