| Cat. No. |
Product Name |
Information |
| PC-21637 |
ZYIL1
NLRP3 inhibitor
|
ZYIL1 is an oral small molecule NLRP3 inflammasome inhibitor, exhibits potent (IC50 in nanomolar range) in human whole blood and supresses inflammation caused by the NLRP3 inflammasome. |
| PC-21283 |
NT-0796
NLRP3 inhibitor
|
NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
| PC-21282 |
DFV890
NLRP3 inhibitor
|
DFV890 (IFM-2427) is apotent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation,prevents NLRP3 inflammasome assembly in response to sterile danger signals. |
| PC-21079 |
JT002
NLRP3 inhibitor
|
JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis. |
| PC-20912 |
JT001
NLRP3 inhibitor
|
JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly. |
| PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |
| PC-20225 |
JC2-11
Inflammasome inhibitor
|
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
| PC-49812 |
ML146
NOD1 inhibitor
|
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
| PC-49811 |
GSK223
NOD1 inhibitor
|
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase. |
| PC-49809 |
FK 156
NOD1 agonist
|
FK156 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49268 |
NDT-30805
NLRP3 inhibitor
|
NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs. |
