Chemical Structure : VEN-02XX
CAS No.:
VEN-02XX
Catalog No.: PC-24562Not For Human Use, Lab Use Only.
VEN-02XX is a a novel potent and selective brain-penetrant small molecule NLRP3 inhibitor with binding KD of 93.3 nM, inhibits IL-1β production in PBMCs with IC50 of 0.35 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VEN-02XX is a a novel potent and selective brain-penetrant small molecule NLRP3 inhibitor with binding KD of 93.3 nM, inhibits IL-1β production in PBMCs with IC50 of 0.35 uM.
VEN-02XX induces NLRP3 inhibition in various cellular systems with sub-micromolar potency including peripheral blood mononuclear cell (PBMC), iPSC-derived microglia and whole blood.
VEN-02XX is lack of TNFα inhibition in cellular assay, also does not block IL-1β release downstream of other inflammasomes like absent in melanoma 2 (AIM2), NOD-like-receptor containing a Pyrin domain 1 (NLRP1) and the NLR-family CARD domain-containing protein 4 (NLRC4).
VEN-02XX significantly reduced microgliosis and neuroinflammation, limited neurodegeneration, and dramatically improved memory and cognition in a dose-dependent manner.
VEN-02XX (20 mg/kg) treatment improved MAP2 levels in the 5xFAD/Rubicon KO mice.
Physicochemical Properties
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M.Wt
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396.80
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Formula
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C18H16ClF3N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-((1-(4-chloro-2-(trifluoromethyl)phenyl)pyrido[3,4-d]pyridazin-4-yl)amino)-2-methylpropan-2-ol
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References
1. Auger A, et al. NPJ Dement. 2025;1(1):3.
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