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You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-NOD-like Receptor (NLR)-JC-171
JC-171

Chemical Structure : JC-171

CAS No.: 2112809-98-8

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JC-171 (JC171)

Catalog No.: PC-61787Not For Human Use, Lab Use Only.

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.
JC-171 interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo.
JC-171 delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE).

Physicochemical Properties

M.Wt 384.831
Formula C16H17ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide

References

1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124.

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