Catalog No.: PC-35078Not For Human Use, Lab Use Only.
Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
Oridonin is an active diterpenoid compound isolated from the plant Rabdosia Rrubescens, has various pharmacological activities, including antioxidant, anti-tumor capacities and anti-inflammation.
Oridonin inhibits AKT kinase activity (AKT1 and AKT2 IC50=8.4 and 8.9 uM) and interacts with the ATP-binding pocket of AKT, inhibits growth of ESCC in vitro and patient derived xenografts in vivo.
Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation.
