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CY-09

Chemical Structure : CY-09

CAS No.: 1073612-91-5

CY-09 (NLRP3 inhibitor CY-09)

Catalog No.: PC-35137Not For Human Use, Lab Use Only.

CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity.
CY-09 suppresses NLRP3 inflammasome assembly and activation, shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes.

Physicochemical Properties

M.Wt 423.424
Formula C19H12F3NO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzoic acid, 4-[[4-oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]-

References

1. Jiang H, et al. J Exp Med. 2017 Nov 6;214(11):3219-3238.

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