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Nodinitib-1

Chemical Structure : Nodinitib-1

CAS No.: 799264-47-4

Nodinitib-1 (ML-130, CID-1088438, Nodinitib, Noditinib-1)

Catalog No.: PC-45499Not For Human Use, Lab Use Only.

Nodinitib-1 (ML130, Noditinib-1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nodinitib-1 (ML130, Noditinib-1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM.
Nodinitib-1 (ML130) shows no inhibition on NOD1, TNFα (IC50> 20 uM) and dIKKγ/NEMO, MYD88, FLIP, CARD6, APAF1 or NLRC4.
Nodinitib-1 (ML130) inhibits IL-8 production induced by NOD1 ligand and γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level.

Physicochemical Properties

M.Wt 287.3369
Formula C14H13N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 20 mg/mL

Chemical Name/SMILES

1H-Benzimidazol-2-amine, 1-[(4-methylphenyl)sulfonyl]-

References

1. Correa RG, et al. Chem Biol. 2011 Jul 29;18(7):825-32.

2. Khan PM, et al. ACS Med Chem Lett. 2011 Oct 13;2(10):780-785.

3. Zheng W, et al. Biochem Biophys Res Commun. 2012 Apr 20;420(4):762-7.

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